January 21, 2026

Male Factor Infertility: Causes, Diagnosis & Treatment Options

Male factor infertility contributes to 40% of infertility cases, with Shady Grove Fertility reporting a 62% clinical pregnancy rate using advanced treatments. Semen analysis remains the critical first step in evaluating male fertility, examining key parameters like sperm volume, concentration, motility, and morphology to guide treatment decisions.


Key Takeaways

Understanding Semen Analysis: Key Factors in Male Fertility Diagnosis

A semen analysis evaluates four critical parameters: volume (minimum 2cc), concentration (sperm count), motility (movement), and morphology (shape). Abnormal results in any category can indicate underlying issues affecting fertility, making this test essential for accurate diagnosis.

Lifestyle Factors That Impact Sperm Quality

Smoking, excessive alcohol consumption, drug use, obesity, and exposure to environmental toxins significantly reduce sperm health. Men should avoid hot baths/saunas and maintain a healthy weight to optimize fertility potential.

Advanced Procedures for Sperm Retrieval in Severe Cases

For men with no detectable sperm in ejaculate, procedures like PESA (Epididymal Sperm Aspiration) or TESE (Testicular Sperm Extraction) can retrieve viable sperm. These minimally invasive techniques use local anesthesia and have high success rates.

Treatment Options for Male Factor Infertility

Options range from IUI (Intrauterine Insemination) with sperm washing to IVF with ICSI (Intracytoplasmic Sperm Injection). ICSI is particularly effective for severe male infertility, as it directly injects a single sperm into the egg.

Why Repeat Semen Analyses Are Often Necessary

Dr. Esposito recommends repeating tests if initial results are abnormal or lack morphology data. Shady Grove Fertility’s Kruger Strict scale provides more accurate morphology analysis than standard WHO criteria, ensuring better diagnostic reliability.


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