January 20, 2026

Common & Uncommon Infertility Causes Explained

Approximately 1 in 8 couples face infertility, with male and female factors equally responsible. Key causes include PCOS, tubal disease, and age-related decline. Shady Grove Fertility reports a 62% clinical pregnancy rate for male factor infertility using ICSI.


Key Takeaways

Male Factor Infertility: Diagnosis and Treatment Options with ICSI

Male infertility accounts for 40% of cases, often due to low sperm count or motility. Intracytoplasmic Sperm Injection (ICSI) during IVF enables fertilization even with severe male factor infertility, achieving high success rates.

Female Factor Infertility: Key Causes and Effective Treatments

Female infertility (40% of cases) includes ovulatory disorders, tubal blockages, and endometriosis. Treatments range from Clomid for PCOS to surgical removal of fibroids or IVF for tubal disease.

PCOS and Fertility: Clomid Effectiveness for Ovulation Induction

Polycystic Ovary Syndrome (PCOS) causes 85% of ovulatory disorders. Weight loss or Clomid induces ovulation, with 70-80% ovulation success and 40-50% pregnancy rates over six cycles.

Unexplained Infertility Solutions: IVF as a Proven Treatment

10% of infertility cases are unexplained. IVF maximizes egg-sperm interaction and bypasses undiagnosed issues, making it a primary treatment for couples with no identifiable cause.

Age-Related Infertility and Donor Eggs: Increasing Pregnancy Success Rates

Women over 38 face declining egg quality. Donor eggs from women aged 21-32 replicate fertility rates of younger women, offering a 60-70% pregnancy success rate for older patients.


Source: Read full article