ASRM 2016 Study: Embryo Growth Rate & Chromosomal Abnormalities Unlinked

A 2016 ASRM study of 1,237 embryos found no increased chromosomal abnormalities in slower-growing embryos (day 6 blastocysts), challenging assumptions about embryo development rates and IVF success.

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Key Takeaways

Day 5 vs Day 6 Embryo Blastocysts and Aneuploidy Rates

The study revealed no difference in aneuploidy rates between embryos that reached the blastocyst stage on day 5 (537 biopsies) versus day 6 (700 biopsies), indicating slower growth does not correlate with higher chromosomal abnormalities.

Maternal Age and Embryo Chromosomal Abnormalities

With an average maternal age of 37 years, the study highlights advanced maternal age as a more significant predictor of aneuploidy than embryo development speed, aligning with historical infertility data.

Implications for IVF Embryo Selection

Findings suggest clinicians should avoid discarding slower-developing embryos based on growth rate alone, as they may still have viable chromosomal profiles for implantation.

Preimplantation Genetic Screening (PGS) Role in Study

The use of PGS to assess 1,237 embryos provided concrete evidence that delayed embryo development does not inherently increase aneuploidy risk, supporting its role in informed IVF decision-making.

Reassurance for Patients with Slow-Growing Embryos

Patients with embryos reaching blastocysts on day 6 can be reassured that these embryos do not carry elevated chromosomal abnormality risks, promoting confidence in IVF treatment outcomes.

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